- CYP450 Tabelle
- Rifampicin
- Flucloxacillin → Tacrolimus↓, Azol-Antimykotika↓1
- PipTaz → MTX-Elimination↓, Akkumulation insb. high-dose onkolog. Dosen2
- Ciprofloxacin → Theophyllin↑3
- Clarithromycin → CYP3A4-Inhib., u.a. Calciumantagonisten, Statine, pot. fatal mit Colchicin in AKI4
- Cotrimoxazol + RAAS-Inhibitoren → fatale HyperK+5
- Carbapeneme → Valproat↓ 80%
Footnotes
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Veenhof, H., Schouw, H.M., Besouw, M.T.P. et al. Flucloxacillin decreases tacrolimus blood trough levels: a single-center retrospective cohort study. Eur J Clin Pharmacol 76, 1667–1673 (2020). https://doi.org/10.1007/s00228-020-02968-z ↩
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R. Zarychanski, K. Wlodarczyk, R. Ariano, E. Bow, Pharmacokinetic interaction between methotrexate and piperacillin/tazobactam resulting in prolonged toxic concentrations of methotrexate, Journal of Antimicrobial Chemotherapy, Volume 58, Issue 1, July 2006, Pages 228–230, https://doi.org/10.1093/jac/dkl196 ↩
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Antoniou T, Gomes T, Mamdani MM, Juurlink DN. Ciprofloxacin-induced theophylline toxicity: a population-based study. Eur J Clin Pharmacol. 2011 May;67(5):521-6. doi: 10.1007/s00228-010-0985-0. Epub 2011 Jan 14. PMID: 21234553. ↩
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I. F. N. Hung, A. K. L. Wu, V. C. C. Cheng, B. S. F. Tang, K. W. To, C. K. Yeung, P. C. Y. Woo, S. K. P. Lau, B. M. Y. Cheung, K. Y. Yuen, Fatal Interaction between Clarithromycin and Colchicine in Patients with Renal Insufficiency: A Retrospective Study, Clinical Infectious Diseases, Volume 41, Issue 3, 1 August 2005, Pages 291–300, https://doi.org/10.1086/431592 ↩
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Fralick M, Macdonald E M, Gomes T, Antoniou T, Hollands S, Mamdani M M et al. Co-trimoxazole and sudden death in patients receiving inhibitors of renin-angiotensin system: population based study BMJ 2014; 349 :g6196 doi:10.1136/bmj.g6196 ↩